Candidatus Midichloriaceae

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Candidatus Midichloriaceae” Montagna et al., 2013
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Montagna et al., 2013
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N.L. n. Midichloria, type genus of the family; -aceae, ending to denote a family; N.L. fem. pl. n. Midichloriaceae, the family of the genus “Candidatus Midichloria”


Montagna et al (2013): The new family encompasses bacteria associated with a wide range of hosts, from protists to vertebrates, including humans; all of the members of this family that have so far been investigated by transmission electron microscopy have been shown to be intracellular, with a typical Gram-negative cell wall.

Note: This group is sometimes referred to as MALO (midichloria and like organisms).

Note: The following addendum in proof appeared in Montagna et al (2013): On the same day this study was accepted for publication, an advanced online publication presented data on a novel bacterium phylogenetically related to “Ca. M. mitochondrii” (T. Driscoll et al., Genome Biol. Evol. doi:10.1093/gbe/evt036, 2013) and referred to this species and related organisms as “Midichloriaceae,” following a previous informal proposal to rank this bacterial group at the family level, discussed in a recent book chapter (J. J. Gillespie, E. Nordberg, A. F. Azad, and B. W. Sobral, p. 84–141, in A. F. Azad and G. H. Palmer, ed., Intracellular pathogens II: Rickettsiales, 2012).

Note: Similarly, a note was added in proof to Driscoll et al (2013): During the production of this work, a recent publication (Montagna et al. 2013) formally classified a novel Rickettsiales family, Candidatus Midichloriaceae, for which the Rickettsiales endosymbiont of Trichoplax adhaerens is a member.
Bacteria » Pseudomonadota » Alphaproteobacteria » Rickettsiales » Candidatus Midichloriaceae
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Citation Title
Lu et al., 2022, Biomolecules Prevalence of Spotted Fever Group Rickettsia and Candidatus Lariskella in Multiple Tick Species from Guizhou Province, China
Giannotti et al., 2022, Applied and Environmental Microbiology The “Other” Rickettsiales : an Overview of the Family “ Candidatus Midichloriaceae”
Mukhacheva, Kovalev, 2017, Microbial Ecology Bacteria of the Family ‘Candidatus Midichloriaceae’ in Sympatric Zones of Ixodes Ticks: Genetic Evidence for Vertical Transmission
Castelli et al., 2016, Rickettsiales Transmission of Members of the “Candidatus Midichloriaceae” Family to Vertebrates and Possible Involvement in Disease Pathogenesis
Wang et al., 2014, Genome Announcements Complete Genome Sequence of the Endosymbiont of Acanthamoeba Strain UWC8, an Amoeba Endosymbiont Belonging to the “ Candidatus Midichloriaceae” Family in Rickettsiales
Montagna et al., 2013, Applied and Environmental Microbiology “Candidatus Midichloriaceae” fam. nov. (Rickettsiales), an Ecologically Widespread Clade of Intracellular Alphaproteobacteria
Effective publication
Driscoll et al., 2013, Genome Biology and Evolution Bacterial DNA Sifted from the Trichoplax adhaerens (Animalia: Placozoa) Genome Project Reveals a Putative Rickettsial Endosymbiont

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