A microbial factory for defensive kahalalides in a tripartite marine symbiosis


Publication

Citation
Zan et al. (2019). Science 364 (6445)
Names (2)
Abstract
A little help from a friend The Hawaiian sea slug Elysia rufescens grazes on an alga called Bryopsis sp. The alga defends itself from predators using peptide toxins decorated with fatty acids, called kahalalides. Zan et al. wondered if a third party was involved in toxin production (see the Perspective by Mascuch and Kubanek). Within the alga, a species of bacterium with a very reduced genome was discovered to be a factory for the nonribosomal assembly of a family of kahalalides. The authors elucidated the pathways for generating this chemical diversity. It seems that the sea slug not only tolerates the toxins but, to protect itself from being eaten by fish, grazes on the alga to accumulate kahalalide. Science , this issue p. eaaw6732 ; see also p. 1034
Authors
Zan, Jindong; Li, Zhiyuan; Tianero, Ma. Diarey; Davis, Jeanette; Hill, Russell T.; Donia, Mohamed S.
Publication date
2019-06-14
DOI
10.1126/science.aaw6732 

© 2022-2026 The SeqCode Initiative
  All information contributed to the SeqCode Registry is released under the terms of the Creative Commons Attribution (CC BY) 4.0 license