SeqCode Registry
cognitis nomina
  • About
  • Search
  • •
  • Login
  • Register
Authors Bedre

JSON
See as cards

Bedre, Renesh


Publications
4

CitationNamesAbstract
Long intergenic non-coding RNAs modulate proximal protein-coding gene expression and tolerance to Candidatus Liberibacter spp. in potatoes Bedre et al. (2024). Communications Biology 7 (1) Liberibacter
Genome editing of NPR3 confers potato resistance to Candidatus Liberibacter spp Ramasamy et al. (2024). Plant Biotechnology Journal 22 (9) Liberibacter
Inhibition of a conserved bacterial dual-specificity phosphatase confers plant tolerance to Candidatus Liberibacter spp Wang et al. (2024). iScience 27 (3) Liberibacter
Plant hairy roots enable high throughput identification of antimicrobials against Candidatus Liberibacter spp Irigoyen et al. (2020). Nature Communications 11 (1) Liberibacter

Plant hairy roots enable high throughput identification of antimicrobials against Candidatus Liberibacter spp
AbstractA major bottleneck in identifying therapies to control citrus greening and other devastating plant diseases caused by fastidious pathogens is our inability to culture the pathogens in defined media or axenic cultures. As such, conventional approaches for antimicrobial evaluation (genetic or chemical) rely on time-consuming, low-throughput and inherently variable whole-plant assays. Here, we report that plant hairy roots support the growth of fastidious pathogens like Candidatus Liberibacter spp., the presumptive causal agents of citrus greening, potato zebra chip and tomato vein greening diseases. Importantly, we leverage the microbial hairy roots for rapid, reproducible efficacy screening of multiple therapies. We identify six antimicrobial peptides, two plant immune regulators and eight chemicals which inhibit Candidatus Liberibacter spp. in plant tissues. The antimicrobials, either singly or in combination, can be used as near- and long-term therapies to control citrus greening, potato zebra chip and tomato vein greening diseases.
Search