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Strain sc|0037641

Name

Streptomyces clavuligerus

Strain numbers

ATCC 27064 = BCRC 11518 = CBS 226.75 = CCRC 11518 = CECT 3125 = CGMCC 4.1611 = DSM 40751 = DSM 41253 = DSM 738 = IFO 13307 = IMET 43657 = JCM 4710 = KCTC 9095 = NBRC 13307 = NCIMB 12785 = NRRL 3585 = VKM Ac-602

StrainInfo: SI-ID 125802 T

Taxon
Streptomyces clavuligerus
Sample
Soil
Cultures (22)
ATCC 27064 = NRRL 3585 = DSM 738 = DSM 41253 = JCM 4710 = CCRC 11518 = DSM 40751 = IFO 13307 = IMET 43657 = NCIMB 12785 = VKM Ac-602 = NRRL B-3585 = CBS 226.75 = CECT 3125 = CCRC 27064 = KCTC 9095 = AS 4.1611 = NBRC 13307 = BCRC 11518 = NBIMCC 3333 = CDBB 1238 = CGMCC 4.1611
Other Designations (5)
MCRL0774 = KCCS-0710 = DSMZ 738 = DSMZ 40751 = MTCC 1142
Sequences (75)
Associated Publications (65)
  • DOI: 10.1002/j.1460-2075.1990.tb08168.x
    Smith DJ, Burnham MK, Bull JH, Hodgson JE, Ward JM, Browne P, Brown J, Barton B, Earl AJ, Turner G (1990). Beta-lactam antibiotic biosynthetic genes have been conserved in clusters in prokaryotes and eukaryotes.
  • DOI: 10.1128/JB.184.11.3106-3113.2002
    Santamarta I, Rodriguez-Garcia A, Perez-Redondo R, Martin JF, Liras P (2002). CcaR is an autoregulatory protein that binds to the ccaR and cefD-cmcI promoters of the cephamycin C-clavulanic acid cluster in Streptomyces clavuligerus.
  • DOI: 10.1021/bi00479a023
    Salowe SP, Marsh EN, Townsend CA (1990). Purification and characterization of clavaminate synthase from Streptomyces clavuligerus: an unusual oxidative enzyme in natural product biosynthesis.
  • DOI: 10.1111/j.1365-2672.1996.tb03228.x
    Cochet N, Demain AL (1996). Effect of water activity on production of beta-lactam antibiotics by Streptomyces clavuligerus in submerged culture.
  • DOI: 10.1016/j.jbiotec.2004.06.010
    Jin W, Kim HK, Kim JY, Kang SG, Lee SH, Lee KJ (2004). Cephamycin C production is regulated by relA and rsh genes in Streptomyces clavuligerus ATCC27064.
  • DOI: 10.1111/j.1365-2958.2007.05937.x
    Santamarta I, Lopez-Garcia MT, Perez-Redondo R, Koekman B, Martin JF, Liras P (2007). Connecting primary and secondary metabolism: AreB, an IclR-like protein, binds the ARE(ccaR) sequence of S. clavuligerus and modulates leucine biosynthesis and cephamycin C and clavulanic acid production.
  • Song JY, Kim ES, Kim DW, Jensen SE, Lee KJ (2008). Functional effects of increased copy number of the gene encoding proclavaminate amidino hydrolase on clavulanic acid production in Streptomyces clavuligerus ATCC 27064.
  • DOI: 10.1007/s10295-008-0499-2
    Song JY, Kim ES, Kim DW, Jensen SE, Lee KJ (2008). A gene located downstream of the clavulanic acid gene cluster in Streptomyces clavuligerus ATCC 27064 encodes a putative response regulator that affects clavulanic acid production.
  • DOI: 10.1128/AEM.00181-09
    Banos S, Perez-Redondo R, Koekman B, Liras P (2009). Glycerol utilization gene cluster in Streptomyces clavuligerus.
  • DOI: 10.1016/S0076-6879(09)04816-2
    Liras P, Demain AL (2009). Chapter 16. Enzymology of beta-lactam compounds with cephem structure produced by actinomycete.
  • DOI: 10.1099/mic.0.035840-0
    Perez-Redondo R, Santamarta I, Bovenberg R, Martin JF, Liras P (2010). The enigmatic lack of glucose utilization in Streptomyces clavuligerus is due to inefficient expression of the glucose permease gene.
  • DOI: 10.1093/gbe/evq013
    Medema MH, Trefzer A, Kovalchuk A, van den Berg M, Muller U, Heijne W, Wu L, Alam MT, Ronning CM, Nierman WC, Bovenberg RA, Breitling R, Takano E (2010). The sequence of a 1.8-mb bacterial linear plasmid reveals a rich evolutionary reservoir of secondary metabolic pathways.
  • DOI: 10.1073/pnas.1014140107
    Li B, Walsh CT (2010). Identification of the gene cluster for the dithiolopyrrolone antibiotic holomycin in Streptomyces clavuligerus.
  • DOI: 10.1007/s13238-010-0127-6
    Chen W, Qu D, Zhai L, Tao M, Wang Y, Lin S, Price NP, Deng Z (2010). Characterization of the tunicamycin gene cluster unveiling unique steps involved in its biosynthesis.
  • DOI: 10.1111/j.1751-7915.2010.00222.x
    Nardiz N, Santamarta I, Lorenzana LM, Martin JF, Liras P (2010). A rhodanese-like protein is highly overrepresented in the mutant S. clavuligerus oppA2::aph: effect on holomycin and other secondary metabolites production.
  • DOI: 10.1111/j.1365-2958.2011.07743.x
    Santamarta I, Lopez-Garcia MT, Kurt A, Nardiz N, Alvarez-Alvarez R, Perez-Redondo R, Martin JF, Liras P (2011). Characterization of DNA-binding sequences for CcaR in the cephamycin-clavulanic acid supercluster of Streptomyces clavuligerus.
  • DOI: 10.1016/j.jbiotec.2012.09.017
    Robles-Reglero V, Santamarta I, Alvarez-Alvarez R, Martin JF, Liras P (2012). Transcriptional analysis and proteomics of the holomycin gene cluster in overproducer mutants of Streptomyces clavuligerus.
  • DOI: 10.1007/s00253-013-5410-z
    Liras P (2013). Holomycin, a dithiolopyrrolone compound produced by Streptomyces clavuligerus.
  • DOI: 10.1111/1751-7915.12109
    Alvarez-Alvarez R, Rodriguez-Garcia A, Santamarta I, Perez-Redondo R, Prieto-Dominguez A, Martinez-Burgo Y, Liras P (2014). Transcriptomic analysis of Streptomyces clavuligerus DeltaccaR::tsr: effects of the cephamycin C-clavulanic acid cluster regulator CcaR on global regulation.
  • DOI: 10.1590/S1517-83822014005000005
    da Silva Vasconcelos E, de Lima VA, Goto LS, Cruz-Hernandez IL, Hokka CO (2014). Clavulanic acid production by the MMS 150 mutant obtained from wild type Streptomyces clavuligerus ATCC 27064.
  • DOI: 10.1128/AEM.00916-15
    Martinez-Burgo Y, Alvarez-Alvarez R, Rodriguez-Garcia A, Liras P (2015). The Pathway-Specific Regulator ClaR of Streptomyces clavuligerus Has a Global Effect on the Expression of Genes for Secondary Metabolism and Differentiation.
  • DOI: 10.1128/AEM.01701-18
    Alvarez-Alvarez R, Rodriguez-Garcia A, Martinez-Burgo Y, Martin JF, Liras P (2018). Transcriptional Studies on a Streptomyces clavuligerus oppA2 Deletion Mutant: N-Acetylglycyl-Clavaminic Acid Is an Intermediate of Clavulanic Acid Biosynthesis.
  • DOI: 10.1007/s13205-018-1498-2
    Li J, Zhao Z, Zhong W, Zhong C, Zong G, Fu J, Cao G (2018). Impacts of horizontal gene transfer on the compact genome of the clavulanic acid-producing Streptomyces strain F613-1.
  • DOI: 10.3389/fmicb.2019.00244
    Fu J, Qin R, Zong G, Liu C, Kang N, Zhong C, Cao G (2019). The CagRS Two-Component System Regulates Clavulanic Acid Metabolism via Multiple Pathways in Streptomyces clavuligerus F613-1.
  • DOI: 10.1002/ece3.4924
    Ayala-Ruano S, Santander-Gordon D, Tejera E, Perez-Castillo Y, Armijos-Jaramillo V (2019). A putative antimicrobial peptide from Hymenoptera in the megaplasmid pSCL4 of Streptomyces clavuligerus ATCC 27064 reveals a singular case of horizontal gene transfer with potential applications.
  • DOI: 10.3389/fmicb.2019.00580
    Martinez-Burgo Y, Santos-Aberturas J, Rodriguez-Garcia A, Barreales EG, Tormo JR, Truman AW, Reyes F, Aparicio JF, Liras P (2019). Activation of Secondary Metabolite Gene Clusters in Streptomyces clavuligerus by the PimM Regulator of Streptomyces natalensis.
  • DOI: 10.3390/antibiotics8030096
    Pinilla L, Toro LF, Laing E, Alzate JF, Rios-Estepa R (2019). Comparative Transcriptome Analysis of Streptomyces Clavuligerus in Response to Favorable and Restrictive Nutritional Conditions.
  • DOI: 10.1186/s13568-019-0844-z
    Fu J, Qin R, Zong G, Zhong C, Zhang P, Kang N, Qi X, Cao G (2019). The two-component system CepRS regulates the cephamycin C biosynthesis in Streptomyces clavuligerus F613-1.
  • DOI: 10.1128/mSystems.01013-20
    Hwang S, Lee N, Choe D, Lee Y, Kim W, Jeong Y, Cho S, Palsson BO, Cho BK (2021). Elucidating the Regulatory Elements for Transcription Termination and Posttranscriptional Processing in the Streptomyces clavuligerus Genome.
  • DOI: 10.1099/mgen.0.000669
    Gomez-Escribano JP, Algora Gallardo L, Bozhuyuk KAJ, Kendrew SG, Huckle BD, Crowhurst NA, Bibb MJ, Collis AJ, Micklefield J, Herron PR, Wilkinson B (2021). Genome editing reveals that pSCL4 is required for chromosome linearity in Streptomyces clavuligerus.
  • DOI: 10.1007/s00253-022-11805-5
    Pivk Lukancic P, Drcar T, Bruccoleri R, Crnugelj M, Mrak P (2022). Teleocidin-producing genotype of Streptomyces clavuligerus ATCC 27064.
  • DOI: 10.3390/bioengineering9020078
    Patino LF, Aguirre-Hoyos V, Pinilla LI, Toro LF, Rios-Estepa R (2022). Environmental Factors Modulate the Role of orf21 Sigma Factor in Clavulanic Acid Production in Streptomyces Clavuligerus ATCC27064.
  • DOI: 10.1128/AAC.37.1.84
    Xiao X, Hintermann G, Hausler A, Barker PJ, Foor F, Demain AL, Piret J (1993). Cloning of a Streptomyces clavuligerus DNA fragment encoding the cephalosporin 7 alpha-hydroxylase and its expression in Streptomyces lividans.
  • DOI: 10.1139/w05-126
    Wu W, Leblanc SK, Piktel J, Jensen SE, Roy KL (2006). Prediction and functional analysis of the replication origin of the linear plasmid pSCL2 in Streptomyces clavuligerus.
  • Li J, Xiang S, Yang X, Yang K (2009). [Evaluation of the activities of two promoters in Streptomycetes by reporter gene method].
  • DOI: 10.1016/0141-0229(90)90178-s
    Rollins MJ, Jensen SE, Wolfe S, Westlake DW (1990). Oxygen derepresses deacetoxycephalosporin C synthase and increases the conversion of penicillin N to cephamycin C in Streptomyces clavuligerus.
  • DOI: 10.1007/BF00173728
    Piret J, Resendiz B, Mahro B, Zhang JY, Serpe E, Romero J, Connors N, Demain AL (1990). Characterization and complementation of a cephalosporin-deficient mutant of Streptomyces clavuligerus NRRL 3585.
  • DOI: 10.7164/antibiotics.45.269
    Minambres B, Reglero A, Luengo JM (1992). Characterization of an inducible transport system for glycerol in Streptomyces clavuligerus. Repression by L-serine.
  • Zhang JY, Demain AL (1990). Regulation of ACV synthetase: biosynthesis and action.
  • DOI: 10.1007/BF01950159
    Jermini MF, Demain AL (1989). Solid state fermentation for cephalosporin production by Streptomyces clavuligerus and Cephalosporium acremonium.
  • DOI: 10.1128/jb.171.12.6808-6814.1989
    Garcia-Dominguez M, Martin JF, Liras P (1989). Characterization of sugar uptake in wild-type Streptomyces clavuligerus, which is impaired in glucose uptake, and in a glucose-utilizing mutant.
  • DOI: 10.7164/antibiotics.36.208
    Pruess DL, Kellett M (1983). Ro 22-5417, a new clavam antibiotic from Streptomyces clavuligerus. I. Discovery and biological activity.
  • DOI: 10.7164/antibiotics.35.1026
    Jensen SE, Westlake DW, Wolfe S (1982). High performance liquid chromatographic assay of cyclization activity in cell-free systems from Streptomyces clavuligerus.
  • DOI: 10.1016/0378-1097(95)00230-3
    Netolitzky DJ, Wu X, Jensen SE, Roy KL (1995). Giant linear plasmids of beta-lactam antibiotic producing Streptomyces.
  • DOI: 10.1099/00221287-144-11-3229
    Chan M, Sim TS (1998). Malate synthase from Streptomyces clavuligerus NRRL3585: cloning, molecular characterization and its control by acetate.
  • Rius N, Demain AL (1997). Lysine epsilon-aminotransferase, the initial enzyme of cephalosporin biosynthesis in actinomycetes.
  • DOI: 10.1016/s0167-4781(01)00309-8
    Soh BS, Loke P, Sim TS (2001). Cloning, heterologous expression and purification of an isocitrate lyase from Streptomyces clavuligerus NRRL 3585.
  • DOI: 10.1016/j.resmic.2004.03.007
    Tunca S, Yilmaz EI, Piret J, Liras P, Ozcengiz G (2004). Cloning, characterization and heterologous expression of the aspartokinase and aspartate semialdehyde dehydrogenase genes of cephamycin C-producer Streptomyces clavuligerus.
  • DOI: 10.1007/s10295-007-0259-8
    Yilmaz EI, Caydasi AK, Ozcengiz G (2007). Targeted disruption of homoserine dehydrogenase gene and its effect on cephamycin C production in Streptomyces clavuligerus.
  • Hung TV, Malla S, Park BC, Liou K, Lee HC, Sohng JK (2007). Enhancement of clavulanic acid by replicative and integrative expression of ccaR and cas2 in Streptomyces clavuligerus NRRL3585.
  • DOI: 10.1271/bbb.80569
    Kim SJ, Kim JO, Shin CH, Park HW, Kim CW (2009). An approach to strain improvement and enhanced production of clavulanic acid in Streptomyces clavuligerus.
  • DOI: 10.1038/ja.2008.92
    Jnawali HN, Oh TJ, Liou K, Park BC, Sohng JK (2008). A two-component regulatory system involved in clavulanic acid production.
  • Jnawali HN, Lee HC, Sohng JK (2010). Enhancement of clavulanic acid production by expressing regulatory genes in gap gene deletion mutant of Streptomyces clavuligerus NRRL3585.
  • DOI: 10.1016/j.micres.2010.07.005
    Jnawali HN, Liou K, Sohng JK (2010). Role of sigma-factor (orf21) in clavulanic acid production in Streptomyces clavuligerus NRRL3585.
  • DOI: 10.1128/JB.00859-10
    Song JY, Jeong H, Yu DS, Fischbach MA, Park HS, Kim JJ, Seo JS, Jensen SE, Oh TK, Lee KJ, Kim JF (2010). Draft genome sequence of Streptomyces clavuligerus NRRL 3585, a producer of diverse secondary metabolites.
  • DOI: 10.4161/bbug.1.3.11244
    Ozcengiz G, Okay S, Unsaldi E, Taskin B, Liras P, Piret J (2010). Homologous expression of aspartokinase (ask) gene in Streptomyces clavuligerus and its hom-deleted mutant: effects on cephamycin C production.
  • DOI: 10.1007/s11427-013-4507-z
    Guo D, Zhao Y, Yang K (2013). Coordination of glycerol utilization and clavulanic acid biosynthesis to improve clavulanic acid production in Streptomyces clavuligerus.
  • DOI: 10.1038/srep15840
    Li S, Wang W, Li X, Fan K, Yang K (2015). Genome-wide identification and characterization of reference genes with different transcript abundances for Streptomyces coelicolor.
  • DOI: 10.2174/0929866527666200723163655
    Unsaldi E, Kurt-Kizildogan A, Ozcan S, Becher D, Voigt B, Aktas C, Ozcengiz G (2021). Proteomic analysis of a hom-disrupted, cephamycin C overproducing Streptomyces clavuligerus.
  • DOI: 10.1007/s00253-022-12098-4
    Kurt-Kizildogan A, Celik G, Unsaldi E, Ozcan S, Ayaz-Guner S, Ozcengiz G (2022). An integrative-omics analysis of an industrial clavulanic acid-overproducing Streptomyces clavuligerus.
  • DOI: 10.3389/fmicb.2022.1078293
    Zhang C, Zhao Y, Li Z, Wang W, Huang Y, Pan G, Fan K (2022). Molecular mechanism of GylR-mediated regulation of glycerol metabolism in Streptomyces clavuligerus NRRL 3585.
  • DOI: 10.1038/s41597-023-02727-6
    Gong J, Yi JS, Cho HS, Shin CH, Won HJ, Cho BK, Noh M, Yoon YJ (2023). Transcriptome profiles of Streptomyces clavuligerus strains producing different titers of clavulanic acid.
  • Salehghamari E, Hamedi J, Elahi E, Sepehrizadeh Z, Sadeghi M, Muth G (2012). Prediction of the pho regulon in Streptomyces clavuligerus DSM 738.
  • Hojati Z, Salehi Z, Motovali-Bashi M, Korbekandi H, Jami S (2011). Molecular Analysis of the Clavulanic Acid Regulatory Gene Isolated from an Iranian Strain of Streptomyces Clavuligerus , PTCC 1709.
  • Korbekandi H, Darkhal P, Hojati Z, Abedi D, Hamedi J, Pourhosein M (2010). Overproduction of Clavulanic Acid by UV Mutagenesis of Streptomyces clavuligerus.
Outside links and data sources
Retrieved 5 months ago via StrainInfo API (CC BY 4.0)

Metadata

Cannonical URL
https://seqco.de/s:37641
Local history
  • Registered 12 months ago
  • Last modified 5 months ago
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