Bolam, David N.


Cryptic diversity of cellulose-degrading gut bacteria in industrialized humans

Moraïs et al. (2024). Science 383 (6688)
Ruminococcus ruminiciens Ruminococcus primiciens Ruminococcus hominiciens
Humans, like all mammals, depend on the gut microbiome for digestion of cellulose, the main component of plant fiber. However, evidence for cellulose fermentation in the human gut is scarce. We have identified ruminococcal species in the gut microbiota of human populations that assemble functional multienzymatic cellulosome structures capable of degrading plant cell wall polysaccharides. One of these species, which is strongly associated with humans, likely originated in the ruminant gut and was