Irigoyen, Sonia


Publications
6

Specifically targeting antimicrobial peptides for inhibition of Candidatus Liberibacter asiaticus

Citation
Mallawarachchi et al. (2024). Journal of Applied Microbiology 135 (4)
Names
Ca. Liberibacter asiaticus
Abstract
Abstract Aims Huanglongbing (citrus greening) is a plant disease putatively caused by the unculturable Gram-negative bacterium Candidatus Liberibacter asiaticus (CLas), and it has caused severe damage to citrus plantations worldwide. There are no definitive treatments for this disease, and conventional disease control techniques have shown limited efficacy. This work presents an in silico evaluation of using specifically targeting anti-microbia

Evaluation of Candidatus Liberibacter Asiaticus Efflux Pump Inhibition by Antimicrobial Peptides

Citation
Wang et al. (2022). Molecules 27 (24)
Names
Liberibacter
Abstract
Citrus greening, also known as Huanglongbing (HLB), is caused by the unculturable bacterium Candidatus Liberibacter spp. (e.g., CLas), and has caused a devastating decline in citrus production in many areas of the world. As of yet, there are no definitive treatments for controlling the disease. Antimicrobial peptides (AMPs) that have the potential to block secretion-dependent effector proteins at the outer-membrane domains were screened in silico. Predictions of drug-receptor interactions were b

Plant hairy roots enable high throughput identification of antimicrobials against Candidatus Liberibacter spp

Citation
Irigoyen et al. (2020). Nature Communications 11 (1)
Names
Liberibacter
Abstract
AbstractA major bottleneck in identifying therapies to control citrus greening and other devastating plant diseases caused by fastidious pathogens is our inability to culture the pathogens in defined media or axenic cultures. As such, conventional approaches for antimicrobial evaluation (genetic or chemical) rely on time-consuming, low-throughput and inherently variable whole-plant assays. Here, we report that plant hairy roots support the growth of fastidious pathogens like Candidatus Liberibac