Nucleic Acids Research


Sequence specific integration by the family 1 casposase from Candidatus Nitrosopumilus koreensis AR1

Wang et al. (2021). Nucleic Acids Research 49 (17)
Ca. Nitrosopumilus koreensis
Abstract Casposase, a homolog of Cas1 integrase, is encoded by a superfamily of mobile genetic elements known as casposons. While family 2 casposase has been well documented in both function and structure, little is known about the other three casposase families. Here, we studied the family 1 casposase lacking the helix-turn-helix (HTH) domain from Candidatus Nitrosopumilus koreensis AR1 (Ca. N. koreensis). The determinants for integration by Ca. N. koreensis casposase were extens